Shopping Cart » DIVAATM     » Cell Invasion     » PathClear® BME     » PARP     » CometAssayTM     » HT 8-oxo-dG ELISA  Home » Angiogenesis & Cell Differentiation Angiogenesis & Cell Differentiation Cultrex® 3D Culture Cell Proliferation Assay Core Kit Recent studies indicate that the composition of the extracellular environment influences cellular responses to apoptosis inducing agents1, 2 implicating a role for extracellular proteins in influencing both toxicity and drug resistance. As a result, this environment must be mimicked during the course of cell-based studies to provide the most accurate translation to animal models The Cultrex® 3-D Culture Cell Proliferation Assays provide a more physiologically relevant assessment when using cell models in the screening process for compounds that influence toxicity. These assays offer a flexible, standardized, high-throughput format for quantitating the degree to which pharmacological compounds influence toxicity or tumorigenicity within in vivo-like environments. The Cultrex® 3-D Culture Cell Proliferation Assay has been adapted to multiple formats so that cell proliferation may be evaluated within different extracellular matrices; BME, Laminin I, and Collagen I and is also available without a matrix.   Applications: tests for the inhibition of proliferation and formation of 3D structures in a matrix of your choice   Components: Part # Component Size   3445-096-02 Cell Proliferation Reagent 3 ml   3445-096-03 3D Culture Stripwells 96 well 2 plates   Storage: Components are stored at -20ºC and at room temperature.   References: 1. Aoudjit F, Vuori K. (2001) Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells. Oncogene 20:4995-5004. 2. Hodkinson PS, Elliott T, Wong WS, Rintoul RC, Mackinnon AC, Haslett C, T Sethi. (2006) ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through ß1 integrin-dependent activation of PI3-kinase. Cell Death and Differentiation 13, 1776-88.   Top   Ordering Information Catalog #: Price: 3445-096-CK Cultrex 3D Culture Cell Proliferation Assay Core Kit, 96 Tests $125.00 Trevigen Products are now available for ordering through Download Protocols Related Products Cultrex 3D Culture Matrix Cell Harvesting Kit Cultrex 3D Culture 96 Well BME Cell Proliferation Assay Cultrex 3D Culture 96 Well Collagen I Cell Proliferation Assay Cultrex 3D Culture 96 Well Laminin I Cell Proliferation Assay Cultrex 3D Culture Matrix Rat Collagen I Cultrex 3D Culture Matrix Laminin I Cultrex 3D Culture Matrix BME TREVIGEN INC. :: 8405 HELGERMAN CT. :: GAITHERSBURG, MD 20877 1.800.TREVIGEN :: 1.800.873.8443 :: (FAX) 1.301.560.4973 :: INFO@TREVIGEN.COM