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Vascular Endothelial Growth Factor (VEGF), Murine

VEGF is a powerful growth factor that stimulates cellular proliferation and survival of endothelial cells and promotes angiogenesis and vascular permeability. VEGF is expressed primarily in vascularized tissues and has been implicated in the induction of tumor metastasis and intraocular neovascular syndromes. Activation occurs through three of the VEGF receptors: fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of human KDR is the flk-1 gene product) and the flt- 4 gene product. VEGF works synergistically with FGF-2 to dramatically amplify angiogenesis. VEGF is provided in 1 µg amounts and qualified in the Directed In Vivo Angiogenesis Assay (DIVAA™).

Source: DNA sequence corresponding to the mouse VEGF protein was expressed in Sf 21 insect cells using baculovirus expression.
 
Activity: The biological activity of recombinant murine VEGF was monitored in a mitogenic assay by measuring VEGF-dependent Hthymidineincorporation in human vascular endothelial (HUVE) cells.
 
Storage Buffer: PBS and 1 mg/mL BSA.
 
Storage: Components are stored at -20°C in a manual defrost freezer.
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Catalog #: Price:

3443-050-03
Cultrex Murine Vascular Endothelial Growth Factor,
1 ug
$85.00
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