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Anti-Mcl-1 Polyclonal Antibody

Mcl-1 is a Bcl-2 homolog involved in early induction of cellular differentiation. Cloned from the human myeloblastic leukemia cell line, Mcl-1 is a 40 kDa mitochondrial protein that has been shown to inhibit apoptosis through the formation of dimers with Bcl-2 family member Bax. Mcl-1 is expressed in a wide variety of cancerous tissues.

Immunogen: Anti-Mcl-1 is a rabbit polyclonal antibody generated by immunization with a KLH-coupled synthetic peptide corresponding to amino acids 175 to 194 of the human Mcl-1 sequence. The murine sequence differs by a single amino acid substitution of S for A at position 192 of human Mcl-1.
 
Source: Rabiit
 
Preparation: The antibody is affinity purified and provided in sterile PBS (pH 7.4) containing 0.01% sodium azide.
 
Specificity: The antibody recognizes human Mcl-1. The antibody also detects a 27-34 kDa band in extracts of mouse L929 and DA3 cells believed to be the murine form of Mcl-1.
 
Applications: Western blotting
 
Controls: Recombinant Murine Mcl-1 (Cat# 2316-050-01) available separately.
 
Storage: Freeze in working aliquots at -20 C in a manual defrost freezer to avoid repeated freeze-thawing.
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Ordering Information
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Catalog #: Price:

2316-PC-075
Anti-Mcl-1 Polyclonal Antibody,
75 µg
$245.00
Add to Cart

2316-050-01
Mcl-1 Western Blot Standard,
50 µl
$70.00
Add to Cart

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