Anti-XIAP Polyclonal Antibody
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Members of the IAP (Inhibitor of
Apoptosis Protein) family were initially identified in baculoviruses.
IAPs are found in a wide variety of organisms from vertebrates
to insects (Drosophila), yeast to invertebrates (Caenorhabditis
elegans). XIAP, cIAP-1, and cIAP-2 are thought to inhibit apoptosis
through direct caspase inhibition. The antiapoptotic range of
action of IAPs is broad and overlaps with Bcl-2 family activity.
All IAP proteins contain at least one 70 amino acid baculovirus
IAP repeats (BIR) which is essential for their anti-cell death
activity that is thought to work by protein-protein interaction.
A common characteristic of the caspase-binding IAP protein (XIAP,
cIAP-1 and cIAP-2) is that they all exhibit three BIR domains
in their sequence.
Similarly to cIAP-1 and cIAP-2, XIAP (X Chromosome-Linked
Inhibitor of Apoptosis) is a mammalian IAP believed to be
involved in apoptosis inhibition through binding specifically
to caspase 3 and caspase 7.
| Immunogen: |
Anti-XIAP is a goat polyclonal antibody corresponding to amino acids I-497 of the human XIAP sequence. |
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| Source: |
Goat |
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| Specificity: |
The antibody recognizes human, mouse, and rat XIAP. |
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| Preparation: |
The antibody is affinity purified and provided in sterile PBS containing 0.02% sodium azide. |
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| Applications: |
Western blotting
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| Storage: |
Freeze in working aliquots at -20°C in a manual defrost freezer to avoid repeated freeze-thawing. |
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