Overview
Oxidative stress, which leads to DNA damage, is a primary driver leading to the accumulation of mutations which occurs in living organisms. The estimated frequency of oxidatively-induced lesions is approximately 104/cell/day. The most extensively investigated, and most abundant DNA lesion generated following exposure to hydroxyl radicals, is 8-hydroxy-2’-deoxy-guanosine (8-oxo-dG). Trevigen now offers two products to enable investigators to monitor changes in 8-oxo-dG levels: a high throughput (HT) 8-oxo-dG ELISA Kit, and 8-oxo-dG monoclonal antibody for immunohistochemical, and immunocytochemical detection. Trevigen also offers research kits targeting biomarkers of oxidative stress. These kits employ well-established methods to assay for superoxide dismutase (SOD), glutathione reductase, glutathione peroxidase, or glutathione, which directly and indirectly measure cellular defensive responses against oxidative stress. Cellular responses to oxidative stress are of interest to investigators of a wide variety of human diseases such as: cancer, diabetes, atherosclerosis, stroke, Alzheimer’s, many auto-immune diseases, and aging.