8-hydroxy-2'-deoxyguanosine (8-oxo-dG) is a modified nucleoside, which is the most commonly studied and detected by-product of DNA damage, caused by oxidative radicals associated with inflammation, carcinogenesis, Parkinson's and Alzheimer's diseases, and also aging. 8-oxo-dG can serve as a sensitive indicator of physiological and environmental damage to DNA. This mouse monoclonal antibody is provided to enable the detection of 8-oxo-dG by ELISA, immunohistochemistry, or by immunocytochemistry.
This mouse monoclonal antibody specifically binds to 8-hydroxy-2'- deoxyguanosine within DNA
This antibody is provided as purified immunoglobulin from mouse ascites in 1X PBS containing
0.01% sodium azide.
Freeze in working aliquots at -20°C in a manual defrost freezer to avoid repeated freeze-thawings.
1. Soultanakis RP, Melamede RJ, Bespalov IA, Wallace SS, Beckman KB, Ames BN, Taatjes DJ, Janssen-Heininger YMW. (2000) Flourescence detection of 8-oxoguanine in nuclear and mitochondrial DNA of cultured cells using a recombinant Fab and confocal scanning laser microscopy. Free Rad Biol Med 28:987-998.