Anti-8-oxo-dG Monoclonal Antibody (clone 2E2)



Catalog #Product NameSizePrice
4354-MC-050 Anti-8-oxo-dG Monoclonal Antibody (clone 2E2)50 µl$415.00

APPLICATIONS:

  • ELISA
  • Immunocytochemistry
  • Immunohistochemistry

8-hydroxy-2'-deoxyguanosine (8-oxo-dG) is a modified nucleoside, which is the most commonly studied and detected by-product of DNA damage, caused by oxidative radicals associated with inflammation, carcinogenesis, Parkinson's and Alzheimer's diseases, and also aging. 8-oxo-dG can serve as a sensitive indicator of physiological and environmental damage to DNA. This mouse monoclonal antibody is provided to enable the detection of 8-oxo-dG by ELISA, immunohistochemistry, or by immunocytochemistry.

IMMUNOGEN:

8-oxo-dG-conjugated-KLH

SOURCE:

Mouse

SPECIFICITY:

This mouse monoclonal antibody specifically binds to 8-hydroxy-2'- deoxyguanosine within DNA

ISOTYPE:

IgG2b.

PREPARATION:

This antibody is provided as purified immunoglobulin from mouse ascites in 1X PBS containing

0.01% sodium azide.

STORAGE:

Freeze in working aliquots at -20°C in a manual defrost freezer to avoid repeated freeze-thawings.

REFERENCES:

1. Soultanakis RP, Melamede RJ, Bespalov IA, Wallace SS, Beckman KB, Ames BN, Taatjes DJ, Janssen-Heininger YMW. (2000) Flourescence detection of 8-oxoguanine in nuclear and mitochondrial DNA of cultured cells using a recombinant Fab and confocal scanning laser microscopy. Free Rad Biol Med 28:987-998.