Tools to Study Genomic Instability and Genotoxic Stress DNA Repair Gene Knockdown Cell Lines*
DNA repair proteins maintain the stability of the genome. When repair protein function is impaired through mutations, the genome may become unstable which is a hallmark of solid tumors. The availability of this panel of knockdown cell lines will permit scientists to study the molecular etiology of tumor genomic instability and to exploit it in oncology research. The Knockdown line encompasses the Base Excision Repair pathway, Non Homologous End Joining, and Mismatch Repair pathways.
Trevigen’s Knockdown Cell Lines are target specific LN428 (glioblastoma) shRNA lentivirus transduced cells. They are rigorously qualified and mycoplasma free. The percent knockdown levels range from 63-98% as evaluated by RT-PCR. Lentiviruses are maintained by puromycin selection.
FEATURES:
- Tested negative for Mycoplasma
- Tested negative for: Human immunodeficiency virus (HIV1, HIV2), Hepatitis viruses (A, B,and C), Human T-lymphotropic virus (HTLV 1, HTLV 2), Epstein Barr, Hantaviruses Hantaan (Seoul, Sin, Nombre), Herpes simplex (1+2,) Human cytomegalovirus, Human herpes virus (6+8), Human adenovirus, Varicella virus and Lymphocytic Choriomeningitis virus.
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